ScienceDaily: Genetics News

Advanced biological computer developed

Thu, 23 May 2013 18:03:03 EDT

Using only biomolecules, scientists have developed and constructed an advanced biological transducer, a computing machine capable of manipulating genetic codes, and using the output as new input for subsequent computations.

Vaccine blackjack: IL-21 critical to fight against viral infections

Thu, 23 May 2013 16:22:22 EDT

Scientists have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.

Cinnamon compound has potential ability to prevent Alzheimer's

Thu, 23 May 2013 14:37:37 EDT

Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important benefit? The common baking spice might hold the key to delaying the onset of -- or warding off -- the effects of Alzheimer's disease.

Biophysicists measure mechanism that determines fate of living cells

Thu, 23 May 2013 14:37:37 EDT

For the first time, biophysicists have measured the molecular force required to mechanically transmit function-regulating signals within a cell. A new laboratory method, named the tension gauge tether approach, has made it possible to detect and measure the mechanics of the single-molecule interaction by which human cell receptors are activated.

New target to boost plant resistance to insects and pathogens identified

Thu, 23 May 2013 14:33:33 EDT

Plants have evolved unique and sophisticated immune systems to defend themselves against insects and pathogens. Plant hormones called jasmonates play an important role in this defense, but jasmonates have been found to also be important for plant growth. Now, researchers have discovered a gene in the jasmonate pathway that controls plant defenses but does not play a detectable role in plant development. These findings could be applied to improve crop resistance in agriculture.

Biochemistry: Unspooling DNA from nucleosomal disks

Thu, 23 May 2013 08:30:30 EDT

The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. This study describes a mechanism that allows chromosomal DNA to be locally displaced from nucleosomes for transcription.

Boosting body's natural flu killers as way to offset virus mutation problem

Thu, 23 May 2013 08:30:30 EDT

The known difficulty in fighting influenza (flu) is the ability of the flu viruses to mutate and thus evade various medications that were previously found to be effective. Researchers at the Hebrew University of Jerusalem have shown recently that another, more promising, approach is to focus on improving drugs that boost the body’s natural flu killer system.

Fast new, one-step genetic engineering technology

Wed, 22 May 2013 13:12:12 EDT

A new, streamlined approach to genetic engineering drastically reduces the time and effort needed to insert new genes into bacteria, the workhorses of biotechnology, scientists are reporting. The method paves the way for more rapid development of designer microbes for drug development, environmental cleanup and other activities.

Slowing the aging process -- only with antibiotics

Wed, 22 May 2013 13:11:11 EDT

Scientists reveal the mechanism responsible for aging hidden deep within mitochondria -- and dramatically slow it down in worms by administering antibiotics to the young.

Norway spruce genome sequenced: Largest ever to be mapped

Wed, 22 May 2013 13:10:10 EDT

Scientists have mapped the gene sequence of Norway spruce (the Christmas tree) -- a species with huge economic and ecological importance -- and that is the largest genome to have ever been mapped. The genome is complex and seven times larger than that of humans.

How immune system peacefully co-exists with 'good' bacteria

Wed, 22 May 2013 13:09:09 EDT

The human gut is loaded with helpful bacteria microbes, yet the immune system seemingly turns a blind eye. Now, researchers know how this friendly truce is kept intact. Innate lymphoid cells directly limit the response by inflammatory T cells to commensal bacteria in the gut of mice. Loss of this ILC function effectively puts the immune system on an extended war footing against the commensal bacteria a condition observed in multiple chronic inflammatory diseases.

Drought makes Borneo's trees flower at the same time

Wed, 22 May 2013 08:53:53 EDT

Tropical plants flower at supra-annual irregular intervals. In addition, mass flowering is typical for the tropical forests in Borneo and elsewhere, where hundreds of different plant timber species from the Dipterocarpaceae family flower synchronously. This phenomenon is all the more puzzling because both temperature and day length are relatively constant all year round due to geographical proximity to the equator.

DNA damage: The dark side of respiration

Wed, 22 May 2013 08:53:53 EDT

Adventitious changes in cellular DNA can endanger the whole organism, as they may lead to life-threatening illnesses like cancer. Researchers now report how byproducts of respiration cause mispairing of subunits in the double helix.

Mechanism discovered which aids Legionella to camouflage itself in the organism

Wed, 22 May 2013 08:52:52 EDT

The feared Legionella pneumophilabacteria is responsible for legionellosis, an infectious disease that can lead to pneumonia. In order to infect us, this pathogen has developed a complex method enabling it to camouflage itself and go unnoticed in our cells, thus avoiding these acting against the infectious bacteria.

Minus environment, patterns still emerge: Computational study tracks E. coli cells' regulatory mechanisms

Tue, 21 May 2013 19:41:41 EDT

Random mutations and genetic drift, rather than design principles, may explain the emergence of regulatory network properties in E. coli.

Bacterium uses natural 'thermometer' to trigger diarrheal disease, scientists find

Tue, 21 May 2013 19:40:40 EDT

How does the bacterium Shigella -- the cause of a deadly diarrheal disease -- detect that it's in a human host? Scientists have found that a biological "RNA thermometer" monitors whether the environment is right for the bacterium to produce the factors it needs to survive within the body, according to a new study.

Single-cell transfection tool enables added control for biological studies

Tue, 21 May 2013 13:22:22 EDT

Researchers have developed a novel tool for single-cell transfection, in which they deliver molecules into targeted cells through temporary nanopores in the cell membrane created by a localized electric field.

Small but speedy: Short plants live in the evolutionary fast lane

Tue, 21 May 2013 12:14:14 EDT

Biologists have known for a long time that some creatures evolve more quickly than others. Exactly why isn't well understood, particularly for plants. But it may be that height plays a role. Shorter plants have faster-changing genomes.

'Whodunnit' of Irish potato famine solved

Tue, 21 May 2013 01:12:12 EDT

An international team of scientists reveals that a unique strain of potato blight they call HERB-1 triggered the Irish potato famine of the mid-19th century.

Parasitic wasps use calcium pump to block fruit fly immunity

Mon, 20 May 2013 16:37:37 EDT

Parasitic wasps switch off the immune systems of fruit flies by draining calcium from the flies' blood cells, a finding that offers new insight into how pathogens break through a host's defenses. Researchers say their findings have uncovered an important component of cellular immunity, one that parasites have learned to take advantage of.

Compound in Mediterranean diet makes cancer cells 'mortal'

Mon, 20 May 2013 15:43:43 EDT

New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells' "superpower" to escape death.

Fastest measurements ever made of ion channel proteins

Mon, 20 May 2013 15:42:42 EDT

Engineers have used miniaturized electronics to measure the activity of individual ion-channel proteins with temporal resolution as fine as one microsecond, producing the fastest recordings of single ion channels ever performed. They designed a custom integrated circuit to perform these measurements, in which an artificial cell membrane and ion channel are attached directly to the surface of the amplifier chip.

Advance in nanotech gene sequencing technique

Mon, 20 May 2013 13:37:37 EDT

The allure of personalized medicine has made new, more efficient ways of sequencing genes a top research priority. One promising technique involves reading DNA bases using changes in electrical current as they are threaded through a nanoscopic hole. Now, physicists has used solid-state nanopores to differentiate single-stranded DNA molecules containing sequences of a single repeating base.

Archaeological genetics: It's not all as old as it at first seems

Mon, 20 May 2013 09:51:51 EDT

Genomic analyses suggest that patterns of genetic diversity which indicate population movement may not be as ancient as previously believed, but may be attributable to recent events.

Making ice-cream more nutritious with meat left-overs

Mon, 20 May 2013 09:48:48 EDT

Most of the animal proteins found in the meat industry waste have, until now, been underutilized. The challenge is to transform such waste into food of higher functionality and added value.

Origins of life: In early Earth, iron helped RNA catalyze electron transfer

Sun, 19 May 2013 14:56:56 EDT

A new study shows how complex biochemical transformations may have been possible under conditions that existed when life began on the early Earth. The study shows that RNA is capable of catalyzing electron transfer under conditions similar to those of the early Earth.

Now we know why old scizophrenia medicine works on antibiotics-resistant bacteria

Sat, 18 May 2013 15:37:37 EDT

An old medicine for schizophrenia is effective at treating something completely different than it was designed for: antibiotic-resistant bacteria. So far it has been a mystery how this old schizophrenia medicine works, but now researchers have figured it out. This can lead to a new medicine against the increasingly threatening antibiotic-resistant bacteria.

Genome sequence of Tibetan antelope sheds new light on high-altitude adaptation

Fri, 17 May 2013 10:27:27 EDT

How can the Tibetan antelope live at elevations of 4,000-5,000m on the Qinghai-Tibetan Plateau? Investigators now provide evidence of genetic factors that may be associated with the species' adaption to harsh highland environments.

Developmental genetics of space and time

Wed, 15 May 2013 16:39:39 EDT

Scientists have conducted a study that reveals important and useful insights into how and why developmental genes often take inputs from two independent “morphogen concentration gradients.”

Untangling the tree of life

Wed, 15 May 2013 09:48:48 EDT

Phylogeneticists examined the reasons why large-scale tree-of-life studies are producing contradictory results and have proposed a suite of novel techniques to resolve the conflicts.

Cells must use their brakes moderately for effective speed control

Wed, 15 May 2013 08:53:53 EDT

How cells regulate their own function by “accelerating and braking” is important basic knowledge when new intelligent medicines are being developed, or when plant cells are tweaked to produce more bioenergy. Scientists now show a model of how cells’ regulatory systems work.

Study IDs key protein for cell death

Tue, 14 May 2013 19:06:06 EDT

Findings may offer a new way to kill cancer cells by forcing them into an alternative programmed-death pathway.

Same musicians play a brand new tune: Unusual interplay of signaling pathways shapes critical eye structure

Tue, 14 May 2013 13:54:54 EDT

A small ensemble of musicians can produce an infinite number of melodies, harmonies and rhythms. So too, do a handful of workhorse signaling pathways that interact to construct multiple structures that comprise the vertebrate body. In fact, crosstalk between two of those pathways -- those governed by proteins known as Notch and BMP (for Bone Morphogenetic Protein) receptors -- occurs over and over in processes as diverse as forming a tooth, sculpting a heart valve and building a brain.

Mining the botulinum genome

Tue, 14 May 2013 12:27:27 EDT

Scientists have been mining the genome of C. botulinum to uncover new information about the toxin genes that produce the potent toxin behind botulism.

Alligator stem cell study gives clues to tooth regeneration

Tue, 14 May 2013 10:14:14 EDT

Alligators may help scientists learn how to stimulate tooth regeneration in people, according to new research. For the first time, a global team of researchers has uncovered unique cellular and molecular mechanisms behind tooth renewal in American alligators.

Water governs cell movement: Aquaporins play key role, new research finds

Tue, 14 May 2013 08:53:53 EDT

Water gives life. Researchers now show how the cells in our bodies are driven mainly by water power -- a discovery that in the long run opens the way for a new strategy in cancer therapy.

Most complete database to date of human phosphatases and their substrates

Tue, 14 May 2013 08:53:53 EDT

It is now easier to pinpoint exactly what molecules a phosphatase -- a type of protein that’s essential for cells to react to their environment -- acts upon in human cells, thanks to the free online database DEPOD, created by EMBL scientists. Published today in Science Signaling, the overview of interactions could even help explain unforeseen side-effects of drugs.

New non-GM technology platform for genetic improvement of sunflower oilseed crop

Mon, 13 May 2013 12:32:32 EDT

Scientists have developed techniques for the genetic improvement of sunflowers using a non-GMO based approach. The new technology platform can harness the plant’s own genes to improve characteristics of sunflower, develop genetic traits, which will improve its role as an important oilseed crop.

Serotonin mediates exercise-induced generation of new neurons

Mon, 13 May 2013 11:09:09 EDT

Mice that exercise in running wheels exhibit increased neurogenesis in the brain. Crucial to this process is serotonin signaling. Surprisingly, mice lacking brain serotonin due to a genetic mutation exhibited normal baseline neurogenesis. However, in these serotonin-deficient mice, activity-induced proliferation was impaired, and wheel running did not induce increased generation of new neurons.

Bird flu in live poultry markets are the source of viruses causing human infections

Mon, 13 May 2013 11:09:09 EDT

On 31 March 2013, the Chinese National Health and Family Planning Commission announced human cases of novel H7N9 influenza virus infections. Scientists have now investigated the origins of this novel H7N9 influenza virus.

Molecular basis of strawberry aroma

Mon, 13 May 2013 11:09:09 EDT

You know that summer is here when juicy red strawberries start to appear on the shelves. In Germany, this seasonal fruit has never been more popular: on average 3.5 kilos per head were consumed in 2012 -- a full kilogram more than ten years ago. Scientists decided to find out what gives strawberries their characteristic flavor.

Family trees for yeast cells

Mon, 13 May 2013 08:30:30 EDT

Researchers have developed a revolutionary method to analyze the genomes of yeast families.

Research on cilia heats up: Implications for hearing, vision loss and kidney disease

Sun, 12 May 2013 14:06:06 EDT

Experiments have unearthed clues about which protein signaling molecules are allowed into hollow, hair-like “antennae,” called cilia, that alert cells to critical changes in their environments.

Carnivorous plant throws out 'junk' DNA

Sun, 12 May 2013 14:05:05 EDT

The newly sequenced genome of the carnivorous bladderwort contradicts the notion that vast quantities of noncoding 'junk' DNA are crucial for complex life.

Sacred lotus genome sequence enlightens scientists

Fri, 10 May 2013 18:02:02 EDT

The sacred lotus is a symbol of spiritual purity and longevity. Its seeds can survive up to 1,300 years, its petals and leaves repel grime and water, and its flowers generate heat to attract pollinators. Now researchers report that they have sequenced the lotus genome. Of all the plants sequenced so far -- and there are dozens -- sacred lotus bears the closest resemblance to the ancestor of all eudicots, a broad category of flowering plants that includes apple, cabbage, cactus, coffee and tobacco.

Potential flu pandemic lurks: Influenza viruses circulating in pigs, birds could pose risk to humans

Fri, 10 May 2013 18:02:02 EDT

In the summer of 1968, a new strain of influenza appeared in Hong Kong. This strain, known as H3N2, spread around the globe and eventually killed an estimated 1 million people. A new study reveals that there are many strains of H3N2 circulating in birds and pigs that are genetically similar to the 1968 strain and have the potential to generate a pandemic if they leap to humans. The researchers also found that current flu vaccines might not offer protection against these strains.

Individual efficacy of chemotherapies

Fri, 10 May 2013 07:54:54 EDT

The function of the mitochondria – also defined as “power plants” within the cells – is essential as to whether, and how, some chemotherapeutic agents take effect in tissue. Scientists have thus discovered a significant cell characteristic that could possibly predict the success of therapy.

Gene associated with eczema in dogs identified

Thu, 09 May 2013 18:46:46 EDT

A novel gene associated with canine atopic dermatitis has been identified. The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure, suggesting an aberrant skin barrier as a potential risk factor for atopic dermatitis.

Mapping the embryonic epigenome: How genes are turned on and off during early human development

Thu, 09 May 2013 12:36:36 EDT

A large, multi-institutional research team has published a sweeping analysis of how genes are turned on and off to direct early human development.

Research reveals cancer-suppressing protein 'multitasks'

Thu, 09 May 2013 12:35:35 EDT

The understanding of how a powerful protein called p53 protects against cancer development has been upended by a new discovery.

Studies generate comprehensive list of genes required by innate system to defend sex cells

Thu, 09 May 2013 12:35:35 EDT

Investigators have published studies revealing many previously unknown components of an innate system that defends sex cells -- the carriers of inheritance across generations -- from the ravages of transposable genetic elements.

Genes define the interaction of social amoeba and bacteria

Thu, 09 May 2013 12:34:34 EDT

Researchers have used the model of the social amoeba -- Dictyostelium discoideum -- to identify the genetic controls on how the amoeba differentiate the different bacteria and respond to achieve their goal of destruction.

Engineered spider toxin could be the future of anti-venom vaccines

Wed, 08 May 2013 21:32:32 EDT

New engineered spider protein could be the start of a new generation of anti-venom vaccines, potentially saving thousands of lives worldwide. The new protein is created from parts of a toxin from the reaper spider

Scientists find key to gene-silencing activity

Wed, 08 May 2013 21:32:32 EDT

Scientists have found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells’ activities. The discovery could lead to a powerful new class of drugs against viral infections, cancers and other diseases.

Save the parrots: Macaw genome sequenced

Wed, 08 May 2013 21:30:30 EDT

In a groundbreaking move that provides new insight into avian evolution, biology and conservation, researchers have successfully sequenced the complete genome of a Scarlet macaw for the first time.

A trick to fold proteins more quickly: 'Clever' technique speeds up the analysis of protein dynamics

Wed, 08 May 2013 09:28:28 EDT

Scientists have devised a method to reduce the time used to simulate how proteins take on their signature three-dimensional shape. Such important information to comprehend their function is usually obtained using often very costly experimental techniques.

Combining strategies speeds the work of enzymes

Tue, 07 May 2013 19:58:58 EDT

Enzymes could break down cell walls faster -- leading to less expensive biofuels for transportation -- if two enzyme systems are brought together in an industrial setting, new research suggests.

Genetic variations associated with susceptibility to bacteria linked to stomach disorders

Tue, 07 May 2013 16:42:42 EDT

Two genome-wide association studies and a subsequent meta-analysis have found that certain genetic variations are associated with susceptibility to Helicobacter pylori, a bacteria that is a major cause of gastritis and stomach ulcers and is linked to stomach cancer, findings that may help explain some of the observed variation in individual risk for H pylori infection.

New insights into Ebola infection pave the way for much-needed therapies

Tue, 07 May 2013 13:45:45 EDT

The Ebola virus is among the deadliest viruses on the planet, killing up to 90 percent of those infected. A new study reveals how the most abundant protein making up the Ebola virus -- viral protein 40 -- allows the virus to leave host cells and spread infection to other cells throughout the human body. The findings could lay the foundation for the development of new drugs and strategies for fighting Ebola infection.

Silk and cellulose biologically effective for use in stem cell cartilage repair

Tue, 07 May 2013 12:48:48 EDT

Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibers such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer.