ScienceDaily: Disorders and Syndromes News

Molecular trigger for Alzheimer's disease identified

Mon, 20 May 2013 15:42:42 EDT

Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease -- when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons in the brain.

Far-reaching, microvascular damage found in uninjured side of brain after stroke

Mon, 20 May 2013 13:37:37 EDT

An animal-model study finds far-reaching microvascular damage in the uninjured side of the brain after a stroke. The findings suggest repair of the protective blood-brain barrier may help prevent this breach in the days following the acute injury.

Link between childhood ADHD and obesity revealed in first long-term study

Mon, 20 May 2013 11:39:39 EDT

A new study found men diagnosed as children with attention-deficit/hyperactivity disorder (ADHD) were twice as likely to be obese in a 33-year follow-up study compared to men who were not diagnosed with the condition.

Anabolic steroids may affect future mental health

Mon, 20 May 2013 09:48:48 EDT

There is a link between use of anabolic-androgenic steroids and reduced mental health later in life. This is the main conclusion of a new study on elite male strength athletes. Twenty per cent of the subjects in the study admitted steroid use.

One in 10 teens using 'study drugs,' but parents aren't paying attention

Mon, 20 May 2013 09:44:44 EDT

Just one in 100 parents believe their kids have used prescription stimulants to boost grades, according to a new poll.

Sleep Apnea linked to Alzheimer's

Sun, 19 May 2013 14:56:56 EDT

A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer’s disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.

Now we know why old scizophrenia medicine works on antibiotics-resistant bacteria

Sat, 18 May 2013 15:37:37 EDT

An old medicine for schizophrenia is effective at treating something completely different than it was designed for: antibiotic-resistant bacteria. So far it has been a mystery how this old schizophrenia medicine works, but now researchers have figured it out. This can lead to a new medicine against the increasingly threatening antibiotic-resistant bacteria.

Youth who have their first drink during puberty have higher levels of later drinking

Sat, 18 May 2013 15:37:37 EDT

The earlier the age at which youth take their first alcoholic drink, the greater the risk of later alcohol problems.

Individuals who drink heavily and smoke may show 'early aging' of the brain

Sat, 18 May 2013 15:34:34 EDT

Alcohol treatment interventions work best when patients understand and are actively involved in the process. A first-of-its-kind study looks at the interactive effects of smoking status and age on neurocognition in one-month-abstinent alcohol dependent (AD) individuals in treatment. Results show that AD individuals who currently smoke have more problems with memory, ability to think quickly and efficiently, and problem-solving skills than those who do not smoke, effects which seem to become greater with increasing age.

For combat veterans suffering from post-traumatic stress disorder, 'fear circuitry' in the brain never rests

Sat, 18 May 2013 15:32:32 EDT

Chronic trauma can inflict lasting damage to brain regions associated with fear and anxiety. Previous imaging studies of people with post-traumatic stress disorder, or PTSD, have shown that these brain regions can over-or under-react in response to stressful tasks.

Ketamine shows significant therapeutic benefit in people with treatment-resistant depression

Sat, 18 May 2013 15:32:32 EDT

Drug associated with rapid antidepressant effect in largest clinical trial to-date.

New approach to improving treatment for MS and other conditions

Fri, 17 May 2013 15:24:24 EDT

Working with lab mice models of multiple sclerosis (MS), scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against MS.

Physicist's tool has potential for brain mapping

Thu, 16 May 2013 16:17:17 EDT

Physicists are developing a new tool that uses low-energy near-infrared light and fiber optics for optogenetic stimulation of cells. He believes it will be a useful tool for mapping physical and functional connections in the brain.

Brain makes call on which ear is used for cell phone

Thu, 16 May 2013 16:16:16 EDT

If you're a left-brain thinker, chances are you use your right hand to hold your cell phone up to your right ear, according to a newly published study. The study shows a strong correlation between brain dominance and the ear used to listen to a cell phone.

Depression linked to almost doubled stroke risk in middle-aged women

Thu, 16 May 2013 16:16:16 EDT

Depression among women 47-52 years old is associated with an almost doubled risk of stroke. Researchers call for greater awareness of depression as a preventable risk factor for stroke among younger middle-aged women.

Gene involved in neurodegeneration keeps clock running: Scientists identify another gene important to morning wake-up call

Thu, 16 May 2013 14:26:26 EDT

Scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock. In a study of the common fruit fly, the researchers found the gene, called Ataxin-2, keeps the clock responsible for sleeping and waking on a 24-hour rhythm. Without the gene, the rhythm of the fruit fly's sleep-wake cycle is disturbed, making waking up on a regular schedule difficult for the fly.

Researchers shocked by new statistics on head injuries among people who are homeless

Thu, 16 May 2013 14:26:26 EDT

Men who are heavy drinkers and homeless for long periods of time have 400 times the number of head injuries as the general population, according to a new study by researchers who said they were shocked by their findings.

Fast and painless way to better mental arithmetic? Yes, there might actually be a way

Thu, 16 May 2013 12:39:39 EDT

In the future, if you want to improve your ability to manipulate numbers in your head, you might just plug yourself in. So say researchers who report on studies of a harmless form of brain stimulation applied to an area known to be important for math ability.

Faulty energy production in brain cells leads to disorders ranging from Parkinson's to intellectual disability

Thu, 16 May 2013 12:38:38 EDT

Neuroscientists have shown for the first time that dysfunctional mitochondria in brain cells can lead to learning disabilities. The link between dysfunctional mitochondria and Parkinson's disease is known, but this new research shows that it is also present in other brain disorders.

Study brings greater understanding of tumor growth mechanism

Thu, 16 May 2013 10:55:55 EDT

A new study has for the first time revealed how the loss of a particular tumor suppressing protein leads to the abnormal growth of tumors of the brain and nervous system.

Genetic risk for schizophrenia is connected to reduced IQ

Thu, 16 May 2013 10:53:53 EDT

The relationship between the heritable risk for schizophrenia and low intelligence (IQ) has not been clear. Schizophrenia is commonly associated with cognitive impairments that may cause functional disability. Researchers have now found that individuals with a higher genetic risk for schizophrenia had a lower IQ at age 70 but not at age 11.

Work-related stress linked to increased blood fat levels, cardiovascular health risks

Thu, 16 May 2013 06:38:38 EDT

New results link job stress to dyslipidemia, a disorder that alters the levels of lipids and lipoproteins in the blood. An altered lipid profile is dangerous for the heart.

Posttraumatic stress disorder associated with type 2 diabetes

Thu, 16 May 2013 06:38:38 EDT

The presence of posttraumatic stress disorder is significantly associated with the development of type 2 diabetes.

Brain rewires itself after damage or injury, life scientists discover

Wed, 15 May 2013 16:50:50 EDT

The brain forms complex new circuits after damage to compensate for lost function, often far from the damaged region, life scientists report. The new study identified the exact regions of the brain that take over when the brain's hippocampus is damaged, and is the first demonstration of such neural circuit plasticity.

Repeat brain injury raises soldiers' suicide risk

Wed, 15 May 2013 16:39:39 EDT

Suicide risk is higher among military personnel with more lifetime TBIs, even after controlling for clinical symptom severity. Results of the study show that multiple TBIs, which are common among military personnel, may contribute to increased risk for suicide.

Novel brain training device to reconnect brain and paralyzed limb after stroke

Wed, 15 May 2013 12:48:48 EDT

The world’s first Brain Training Device has given a ray of new hope to the recovery of survivors after stroke. This novel device can detect brainwave and control the movement of paralyzed limbs.

'Good vibrations:' Brain ultrasound improves mood

Wed, 15 May 2013 09:48:48 EDT

Non-invasive brain stimulation techniques aimed at mental and neurological conditions include transcranial magnetic stimulation (TMS) for depression, and transcranial direct current (electrical) stimulation (tDCS), have been shown to improve memory. Transcranial ultrasound stimulation (TUS) has also shown promise.

Getting a grip on sleep

Tue, 14 May 2013 18:45:45 EDT

All mammals sleep, as do birds and some insects. However, how this basic function is regulated by the brain remains unclear. According to a new study, a brain region called the lateral habenula plays a central role in the regulation of REM sleep.

Alzheimer's markers predict start of mental decline

Tue, 14 May 2013 11:26:26 EDT

Using long-term patient data, scientists have found that many of the biomarkers for Alzheimer’s identified in recent years can help accurately predict the start of full-blown disease years in advance.

Flu in pregnancy may quadruple child's risk for bipolar disorder

Tue, 14 May 2013 10:14:14 EDT

Flu in pregnant mothers has been linked to a nearly fourfold increased risk that their child might develop bipolar disorder in adulthood. The findings add to mounting evidence of possible shared underlying causes and illness processes with schizophrenia, which some studies have also linked to prenatal exposure to influenza.

Fish oil may stall effects of junk food on brain

Tue, 14 May 2013 10:14:14 EDT

Data from more than 180 research papers suggests fish oils could minimize the effects that junk food can have on the brain, a review has shown.

Relationship troubles? Some sad music might help you feel better

Tue, 14 May 2013 10:14:14 EDT

Consumers experiencing relationship problems are more likely to prefer aesthetic experiences that reflect their negative mood, according to a new study.

Brain-imaging study links cannabinoid receptors to post-traumatic stress disorder: First pharmaceutical treatment for PTSD within reach

Tue, 14 May 2013 08:50:50 EDT

In a first-of-its-kind effort to illuminate the biochemical impact of trauma, researchers at NYU Langone Medical Center have discovered a connection between the quantity of cannabinoid receptors in the human brain, known as CB1 receptors, and post-traumatic stress disorder, the chronic, disabling condition that can plague trauma victims with flashbacks, nightmares and emotional instability.

New drug reverses memory deficits and slows Alzheimer's in mice

Mon, 13 May 2013 20:24:24 EDT

A drug known as J147 reverses memory deficits and slows Alzheimer's disease in aged mice following short-term treatment. The findings may pave the way to a new treatment for Alzheimer's disease in humans.

Brain frontal lobes not sole center of human intelligence, comparative research suggests

Mon, 13 May 2013 15:28:28 EDT

Human intelligence cannot be explained by the size of the brain's frontal lobes, say researchers. Research into the comparative size of the frontal lobes in humans and other species has determined that they are not -- as previously thought -- disproportionately enlarged relative to other areas of the brain, according to the most accurate and conclusive study of this area of the brain. It concludes that the size of our frontal lobes cannot solely account for humans' superior cognitive abilities.

Out of sync: Body clocks altered at cell level in depression

Mon, 13 May 2013 15:23:23 EDT

Every cell in our bodies runs on a 24-hour clock, tuned to the night-day, light-dark cycles that have ruled us since the dawn of humanity. But new research shows that the clock may be broken in the brains of people with depression -- even at the level of the gene activity inside their brain cells.

Serotonin mediates exercise-induced generation of new neurons

Mon, 13 May 2013 11:09:09 EDT

Mice that exercise in running wheels exhibit increased neurogenesis in the brain. Crucial to this process is serotonin signaling. Surprisingly, mice lacking brain serotonin due to a genetic mutation exhibited normal baseline neurogenesis. However, in these serotonin-deficient mice, activity-induced proliferation was impaired, and wheel running did not induce increased generation of new neurons.

World first clinical trial supports use of Kava to treat anxiety

Mon, 13 May 2013 09:57:57 EDT

A world-first completed clinical study by an Australian team has found Kava, a medicinal South Pacific plant, significantly reduced the symptoms of people suffering anxiety.

To suppress or to explore? Emotional strategy may influence anxiety

Mon, 13 May 2013 08:33:33 EDT

When trouble approaches, what do you do? Run for the hills? Pretend it isn't there? Hide? Or do you focus on the promise of rain in those looming dark clouds? New research suggests that the way you regulate your emotions, in bad times and in good, can influence whether -- or how much -- you suffer from anxiety.

Possible reason for cholesterol-drug side effects such as memory loss

Fri, 10 May 2013 15:01:01 EDT

Researchers have identified a clue to explain the reversible memory loss sometimes caused by the use of statins, one of the most widely prescribed medications. Unusual swellings within neurons, which the team has termed the "beads-on-a-string" effect, may be linked to the cognitive decline some patients experience while taking the cholesterol-lowering drugs.

Study supports alternative model for personality disorders in upcoming DSM-5

Fri, 10 May 2013 12:45:45 EDT

A new "alternative model" included in the upcoming Fifth Edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders lines up well with the current approach to diagnosis of personality disorder, according to a new study.

Cancer drug prevents build-up of toxic brain protein

Fri, 10 May 2013 07:56:56 EDT

Researchers have used tiny doses of a leukemia drug to halt accumulation of toxic proteins in the brains of mice. They say their study offers a unique and exciting strategy to treat neurodegenerative diseases that feature abnormal buildup of proteins in Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington's disease and Lewy body dementia, among others.

Brain diseases affecting more people and starting earlier than ever before

Fri, 10 May 2013 07:55:55 EDT

Scientists have found that the sharp rise of dementia and other neurological deaths in people under 74 cannot be put down to the fact that we are living longer. The rise is because a higher proportion of old people are being affected by such conditions -- and what is really alarming, it is starting earlier and affecting people under 55 years.

Future hospitalization and increased health service use may be linked to insomnia

Fri, 10 May 2013 07:53:53 EDT

New study finds insomnia may be an important indicator of future hospitalization among middle-aged and older adults.

Unleashing the watchdog protein: Research opens door to new drug therapies for Parkinson's disease

Thu, 09 May 2013 15:45:45 EDT

Researchers have unlocked a new door to developing drugs to slow the progression of Parkinson's disease.

Dynamic behavior of progenitor cells in brain discovered

Thu, 09 May 2013 14:21:21 EDT

By monitoring the behavior of a class of cells in the brains of living mice, neuroscientists have discovered that these cells remain highly dynamic in the adult brain, where they transform into cells that insulate nerve fibers and help form scars that aid in tissue repair.

How nerve wiring self-destructs

Thu, 09 May 2013 12:35:35 EDT

Many medical issues affect nerves, from injuries and chemotherapy to glaucoma and multiple sclerosis. The common theme in these scenarios is destruction of nerve axons, the long wires that transmit signals to other parts of the body. Researchers have now found a way the body can remove injured axons, identifying a potential target for new drugs that could prevent the inappropriate loss of axons.

Advance in tuberous sclerosis brain science

Thu, 09 May 2013 12:34:34 EDT

By manipulating the timing of disease-causing mutations in the brains of developing mice, researchers have found that early genetic deletions in the thalamus may play an important role in course and severity of the developmental disease tuberous sclerosis complex.

Parental addictions linked to adult children's depression

Thu, 09 May 2013 12:33:33 EDT

The offspring of parents who were addicted to drugs or alcohol are more likely to be depressed in adulthood, according to a new study. Investigators have examined the association between parental addictions and adult depression in a representative sample of 6,268 adults, drawn from the 2005 Canadian Community Health Survey.

Methylphenidate 'normalizes' activation in key brain areas in kids with ADHD, study suggests

Thu, 09 May 2013 12:33:33 EDT

The stimulant drug methylphenidate "normalizes" activation of several brain areas in young patients with attention-deficit/hyperactivity disorder (ADHD), according to a new review.

Sexual harassment linked to 'purging' -- in men

Thu, 09 May 2013 10:43:43 EDT

Men who experience high levels of sexual harassment are much more likely than women to induce vomiting and take laxatives and diuretics in an attempt to control their weight, according to a surprising finding.

Brain system for emotional self-control discovered

Thu, 09 May 2013 10:43:43 EDT

Different brain areas are activated when we choose to suppress an emotion, compared to when we are instructed to inhibit an emotion, according a new study.

Could eating peppers prevent Parkinson's? Dietary nicotine may hold protective key

Thu, 09 May 2013 09:12:12 EDT

New research reveals that Solanaceae -- a flowering plant family with some species producing foods that are edible sources of nicotine -- may provide a protective effect against Parkinson's disease. The study suggests that eating foods that contain even a small amount of nicotine, such as peppers and tomatoes, may reduce risk of developing Parkinson's.

Chronic pain sufferers likely to have anxiety

Wed, 08 May 2013 21:31:31 EDT

Patients coping with chronic pain should also be evaluated for anxiety disorders, according to new research.

Missing link in signals contributes to neurodegeneration

Wed, 08 May 2013 15:13:13 EDT

In many neurodegenerative diseases the neurons of the brain are over-stimulated and this leads to their destruction. After many failed attempts and much scepticism this process was finally shown last year to be a possible basis for treatment in some patients with stroke. But very few targets for drugs to block this process are known.

Brain anatomy of dyslexia is not the same in men and women, boys and girls

Wed, 08 May 2013 13:18:18 EDT

Using MRI, neuroscientists have found significant differences in brain anatomy when comparing men and women with dyslexia to their non-dyslexic control groups. Their study is the first to directly compare brain anatomy of females with and without dyslexia.

Enhanced motion perception in autism may point to an underlying cause of the disorder

Wed, 08 May 2013 13:18:18 EDT

Children with autism see simple movement twice as quickly as other children their age, and this hypersensitivity to motion may provide clues to a fundamental cause of the developmental disorder, according to a new study.

Weeks after stroke, some patients develop chronic, debilitating pain

Wed, 08 May 2013 12:28:28 EDT

Nearly 1 in 10 stroke patients suffer chronic and debilitating pain, typically described as sharp, stabbing or burning. It is treatable with medications and magnetic or electrical stimulation of the brain. But physicians often fail to correctly diagnose the condition.

Geneticists find causes for severe childhood epilepsies

Wed, 08 May 2013 09:30:30 EDT

Using a DNA sequencing technique capable of deciphering all human genes at the same time, researchers have discovered genetic mutations underlying seizure disorders in previously undiagnosed children.

Why family conflict affects some children more than others

Wed, 08 May 2013 09:28:28 EDT

New research reveals why some children are badly affected by negative family conflicts while other children survive without significant problems. Researchers found that the way in which children understood the conflicts between their parents had different effects on their emotional and behavioral problems. Where children blamed themselves for the conflicts between their parents, they were more likely to have behavioral problems, such as anti-social behavior. But if their parents' fighting or arguing led to a child feeling threatened, or fearful that the family would split up, the child was more likely to experience emotional problems, such as depression.