ScienceDaily: Ulcer News

Genetic variations associated with susceptibility to bacteria linked to stomach disorders

Tue, 07 May 2013 16:42:42 EDT

Two genome-wide association studies and a subsequent meta-analysis have found that certain genetic variations are associated with susceptibility to Helicobacter pylori, a bacteria that is a major cause of gastritis and stomach ulcers and is linked to stomach cancer, findings that may help explain some of the observed variation in individual risk for H pylori infection.

High-salt diet and ulcer bug combine to increase risk of cancer

Thu, 18 Apr 2013 16:23:23 EDT

Numerous epidemiologic studies have shown that a diet high in salt is associated with an increased risk of gastric cancer. Now researchers have shown that high dietary salt combined with infection by the ulcer-causing bacterium Helicobacter pylori greatly increases the risk of cancer.

Other stomach microbiota modulate resistance to H. pylori-driven ulcers

Mon, 25 Mar 2013 13:53:53 EDT

Mice with different naturally occurring stomach bacteria have distinct susceptibilities to disease caused by Helicobacter pylori, the well-known cause of ulcers in humans, according to a new study. This is the first study to document (in mice) that the presence of certain bacteria in the stomach microbiota can prevent pathology from H. pylori.

Some bacteria may protect against disease caused by stomach infection

Tue, 12 Mar 2013 13:47:47 EDT

Half of the world's human population is infected with the stomach bacteria called Helicobacter pylori, yet it causes disease in only about 10 percent of those infected. Other bacteria living in the stomach may be a key factor in whether or not H. pylori causes disease, according to a new study.

Villain stomach bug may have a sweet side: 'Bad' gut bacteria may help control diabetes

Fri, 08 Feb 2013 18:28:28 EST

A stomach bacterium believed to cause health problems such as gastritis, ulcers, and gastric cancer may play a dual role by balancing the stomach's ecosystem and controlling body weight and glucose tolerance, according to immunologists.

Stroke drug kills bacteria that cause ulcers and tuberculosis

Thu, 20 Dec 2012 14:37:37 EST

A drug for ischemic strokes may also treat tuberculosis and ulcers. New research shows the compound, ebselen, to inhibit the thioredoxin reductase system in bacteria, including Helicobacter pylori and Mycobacterium tuberculosis.

Ulcer-causing bacteria tamed by defect in cell-targeting ability

Mon, 21 Nov 2011 15:15:15 EST

Without the ability to swim to their targets in the stomach, ulcer-causing bacteria do not cause the inflammation of the stomach lining that leads to ulcers and stomach cancer, according to a new study.

Foot ulcers: Research identifies factors key to healing diabetes-related foot sores

Wed, 26 Oct 2011 09:10:10 EDT

What’s crucial for a diabetic’s foot sore to heal is that the ulcer is superficial, blood circulation is normal, and the person has had diabetes for short time. This is shown in a large diabetes study regarding foot ulcers, carried out in Sweden.

Strawberries protect the stomach from alcohol, rat experiments suggest

Tue, 25 Oct 2011 09:15:15 EDT

In an experiment on rats, European researchers have proved that eating strawberries reduces the harm that alcohol can cause to the stomach mucous membrane. The study may contribute to improving the treatment of stomach ulcers.

Bacteria associated with stomach ulcers not detected in enlarged adenoids in children

Mon, 17 Oct 2011 17:08:08 EDT

Bacteria that cause stomach inflammation and ulcers were not detectable in tissue from inflamed and enlarged adenoids in children, according to a new report.

Transarterial embolization is a safe, nonoperative option for acute peptic ulcer bleeding, study suggests

Mon, 23 May 2011 12:44:44 EDT

Researchers report that in patients with peptic ulcer bleeding in whom endoscopy failed to control the bleeding, transarterial embolization is a safe procedure which reduces the need for surgery without increasing overall mortality and is associated with few complications.

Ulcer bacteria may contribute to development of Parkinson's disease

Sun, 22 May 2011 14:15:15 EDT

The stomach bacteria responsible for ulcers could also play a role in the development of Parkinson's disease according to new research.

DNA from common stomach bacteria minimizes effects of colitis, study says

Thu, 05 May 2011 18:15:15 EDT

DNA from Helicobacter pylori, a common stomach bacteria, minimizes the effects of colitis in mice, according to a new study.

Probiotic identified to treat ulcers

Thu, 24 Feb 2011 12:19:19 EST

Researchers have identified a strain of probiotic bacteria that may be useful in treating ulcers caused by Helicobacter pylori.

Common stomach bacteria may fight off inflammatory bowel disease caused by Salmonella

Mon, 01 Nov 2010 13:01:01 EDT

Helicobacter pylori, a common stomach bacterium, reduced the severity of inflammation of the colon caused by Salmonella in mice, according to new research.

New evidence of common gastric infection as invasive pathogen may explain antibiotic resistance

Sat, 16 Oct 2010 08:00:00 EDT

Helicobacter pylori, the bacterium largely associated with gastritis and peptic ulcers in humans, may invade and replicate in gastric epithelial cells say researchers from China. This discovery disputes prior views of H. pylori as a noninvasive pathogen and could offer significant insight into its ability to resist antibacterial therapy and its biological life cycle as a whole.

Hemostatic powder stops bleeding ulcers, study suggests

Wed, 13 Oct 2010 12:27:27 EDT

A new material similar to that used by the US military to treat traumatic injuries is showing promise as the next novel treatment for bleeding ulcers, a condition that commonly affects up to 15 percent of adults, according to new research.

Mind over matter? The psychology of healing

Mon, 02 Aug 2010 10:16:16 EDT

People suffering from diabetes-related foot ulcers show different rates of healing according to the way they cope and their psychological state of mind, according to new research by a health psychologist.

Immune system important in fight against stomach cancer

Mon, 28 Jun 2010 07:57:57 EDT

Researchers have identified cells in the immune system that react to the stomach ulcer bacterium Helicobacter pylori, one of the risk factors for the development of stomach cancer. This discovery could lead to faster diagnosis and treatment as well as a better prognosis for patients with stomach cancer.

Treatment of Helicobacter pylori-negative gastric MALT lymphoma

Fri, 07 May 2010 10:18:18 EDT

A research team from South Korea evaluated the treatment outcome of Helicobacter pylori (H. pylori)-negative low-grade gastric mucosa associated lymphoid tissue (MALT) lymphoma patients to offer therapeutic guidelines for such patients. Their results showed that eradication therapy may be offered as an initial treatment option even in cases of localized H. pylori-negative gastric MALT lymphoma.

Breastfeeding protects children against peptic ulcer bacterium, study suggests

Mon, 01 Mar 2010 16:35:35 EST

Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrens´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection.

New finding of the expression of Helicobacter pylori in Chilean patients

Tue, 09 Feb 2010 18:29:29 EST

Helicobacter pylori (H. pylori) colonize the human stomach and present genetic mechanisms to evade the host immune response allowing their persistence in this habitat for years. A study involving 130 H. pylori strains isolated from patients living in different Chilean cities revealed that, nearly half of them carry the hopE and hopV genes. The results suggest that these genes can be turned on and off, and are likely to be involved in avoiding immune recognition.

Gastric ulcer bacteria turn immune defense inwards

Mon, 25 Jan 2010 09:46:46 EST

Despite a strong response from our immune defence, the body is unable to rid itself of the bacterium Helicobacter pylori. One reason for this is that this bacterium encourages elements of the immune response to remain in tissue, activating the wrong immune cells. New research results are paving the way for a future vaccine.

New Combination Therapy Looks Promising Against Ulcer Bacteria

Mon, 26 Oct 2009 12:51:51 EDT

Results of a new study reveal that a seven-day course of LOAD therapy is superior to LAC at eliminating the H. pylori bacterium in patients with gastritis and peptic ulcers.

Important Defence Against Stomach Ulcer Bacterium Identified

Mon, 12 Oct 2009 09:55:55 EDT

A special protein in the lining of the stomach has been shown to be an important part of the body’s defence against the stomach ulcer bacterium Helicobacter pylori in a new study from researchers in Sweden. The discovery may explain why the bacterium makes some people more ill than others.

Taking Sharper Aim At Stomach Ulcer Bacteria

Wed, 30 Sep 2009 11:21:21 EDT

Scientists are reporting discovery of a much sought after crack in the armor of a common microbe that infects the stomachs of one-sixth of the world's population, causing stomach ulcers and other diseases. They identified a group of substances that block a key chemical pathway that the bacteria need for survival.

Does Helicobacter Pylori Eradication Therapy Prevent Gastric Cancer?

Fri, 25 Sep 2009 09:26:26 EDT

A research team from Japan investigated whether eradication of H. pylori in peptic ulcer patients prevented gastric cancer. They found that eradication did not significantly reduce the incidence of cancer in their patients, who had a mean age of 52.9 years at registration, after a mean follow-up period of 5.6 years.

Secrets Of Ulcer-causing Bacteria: Clever Biochemical Strategy Enables Bacteria To Move Freely And Colonize Host

Wed, 12 Aug 2009 16:38:38 EDT

A team of researchers recently made a discovery that changes a long held paradigm about how bacteria move through soft gels. They showed that the bacterium that causes human stomach ulcers uses a clever biochemical strategy to alter the physical properties of its environment, allowing it to move and survive and further colonize its host.

Childhood Adversities Have Predictive Role In Peptic Ulcer

Wed, 29 Jul 2009 09:50:50 EDT

Childhood adversities have a predictive role in peptic ulcer, according to new research. The most common adversities were long-lasting financial difficulties in the family, serious conflicts in the family, and a family member seriously or chronically ill. Age- and sex-adjusted odds ratios of childhood adversities varied between 1.45 and 2.01. Adjusting for smoking, heavy drinking, stress and nonsteroidal anti-inflammatory drug use had no further influence.

Peptic Ulcer Bacterium Alters The Body's Defense System

Mon, 29 Jun 2009 11:28:28 EDT

Helicobacter pylori survives in the body by manipulating important immune system cells. The discovery may lead to new treatments against the common peptic ulcer bacterium.

Gastrin Plays Significant Role In Helicobacter-induced Stomach Cancer

Wed, 24 Jun 2009 16:16:16 EDT

Scientists have studied the role of Helicobacter infection in the development of stomach cancer, and found that the hormone gastrin, which stimulates secretion of gastric acid, plays a key role in the development of Helicobacter-induced stomach cancer, may have distinct effects on carcinogenesis in different parts of the stomach.

Simple Measures May Prevent Transmission Of Stomach Ulcer Bacteria

Wed, 24 Jun 2009 11:19:19 EDT

The stomach ulcer bacterium Helicobacter pylori is not transmitted through drinking water as previously thought, but rather through vomit and possibly feces. It is therefore possible to prevent the spread of the bacterium in developing countries through some fairly simple measures.

Potential Anti-ulcer Herb Medicine: Rocket 'Eruca Sativa'

Thu, 07 May 2009 10:18:18 EDT

A research group from Saudi Arabia studied the anti-ulcer properties of the salad herb rocket, also known as arugula (species Eruca sativa). They found that rocket extract possesses antisecretory, cytoprotective and anti-ulcer activities against experimentally-induced gastric lesions in rats. The anti-ulcer effect is possibly through prostaglandin mediated activity and/or through its anti-secretory and antioxidant properties.

Special Yogurt Fights Stomach Ulcer Bacteria

Sun, 22 Mar 2009 15:44:44 EDT

A new type of yogurt appears to benefit your gut. Results of the first human clinical studies confirm that the new yogurt fights the bacteria that cause gastritis and stomach ulcers with what researchers describe as almost vaccine-like effects, scientists in Japan are reporting.

Maggot Therapy Similar To Standard Care For Leg Ulcers

Thu, 19 Mar 2009 22:45:45 EDT

Larval (maggot) therapy has similar health benefits and costs compared with a standard treatment for leg ulcers, find two studies.

Why Are Tribal Populations In West Bengal, India Free From Clinical Symptoms Infection With H. Pylori Strains?

Mon, 09 Mar 2009 09:30:30 EDT

A research group investigated the changing pattern of different histological parameters occurring in the stomach tissue of Helicobacter pylori-infected asymytomatic tribal Bengali population in West Bengal, India and duodenal ulcer patients. Their study showed almost similar distribution of inflammatory cells between tribals and DU patients. Interestingly, tribal population are free from clinical symptoms despite evidence of active histologic gastritis and infection with Helicobacter pylori strains carrying similar virulence markers as of strains isolated from patients with DU.

Stomach Ulcer Bug Causes Bad Breath

Sun, 23 Nov 2008 22:28:28 EST

Bacteria that cause stomach ulcers and cancer could also be giving us bad breath, according to research published in the Journal of Medical Microbiology. For the first time, scientists have found Helicobacter pylori living in the mouths of people who are not showing signs of stomach disease.

H. Pylori Bacteria May Help Prevent Some Esophageal Cancers

Mon, 06 Oct 2008 09:25:25 EDT

Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live in the stomachs of humans.

Going From Ulcers To Cancer

Fri, 22 Aug 2008 12:01:01 EDT

Researchers have uncovered a big clue as to why some of the bacteria that cause stomach ulcers pose a greater risk for serious problems like stomach cancer than others; it turns out these bacteria can exploit the surrounding stomach cells to protect them from the immune system.

MDCT, Virtual Gastroscopy And MPR Images Differentiate Malignant And Benign Gastric Ulcers

Wed, 16 Jul 2008 11:55:55 EDT

Multidetector CT using virtual gastroscopy and post contrast enhanced multiplanar reformation images can be useful in differentiating between malignant and benign gastric ulcers, according to a recent study.

Stomach Bug Appears To Protect Kids From Asthma, Says New Study

Tue, 15 Jul 2008 07:14:14 EDT

A long-time microbial inhabitant of the human stomach may protect children from developing asthma, according to a new study among more than 7,000 subjects. Helicobacter pylori, a bacterium that has co-existed with humans for at least 50,000 years, may lead to peptic ulcers and stomach cancer. Yet, kids between the ages of 3 and 13 are nearly 59 percent less likely to have asthma if they carry the bug, the researchers report.

The 700-year-old Mexican Mummy With A Tummy Ache

Mon, 14 Jul 2008 19:26:26 EDT

Remnants of the bacterium that causes stomach ulcers, Helicobacter pylori, have been discovered in gastric tissue from North American mummies. A study of human remains believed to predate Columbus' discovery of the New World has shown for the first time that H. pylori infection occurred in native populations.

New Pathogen From Pigs' Stomach Ulcers

Sun, 08 Jun 2008 21:37:37 EDT

Scientists have isolated a new bacterium in pigs' stomachs thanks to a pioneering technique, offering hope of new treatments to people who suffer with stomach ulcers, according to research in the International Journal of Systematic and Evolutionary Microbiology.

Immune Cells May Induce Gastritis During H. Pylori Infection

Fri, 23 May 2008 07:10:10 EDT

Researchers have examined the inflammatory response induced by macrophages that may contribute to the development of gastritis during Helicobacter pylori infection in mice. H. pylori is the causative agent of human chronic gastritis, a condition that often leads to gastrointestinal ulcers and cancer.

Early Treatment Of Stomach Infection May Prevent Cancer

Thu, 01 May 2008 06:27:27 EDT

Based on research using a new mouse model of gastritis and stomach cancer, researchers say that prompt treatment of Helicobacter pylori infections reverses damage to the lining of the stomach that can lead to cancer.

Gastric Juice For Diagnosis Of H. Pylori Infection In Patients On Proton Pump Inhibitors

Wed, 30 Apr 2008 09:33:33 EDT

Scientists have determined that a gastric juice polymerase chain reaction test for the diagnosis of Helicobacter pylori infection has greater sensitivity compared to histology when commonly used potent acid-reducing drugs such as proton pump inhibitors are being used. The use of the gastric juice PCR test can be recommended to confirm H. pylori status in patients taking PPIs.

'Dragon's Blood' Quenches Stomach Ulcer Bacteria

Mon, 12 Nov 2007 10:48:48 EST

"Dragon's blood" may sound like an exotic ingredient in a witch's brew or magic potion. But researchers in China are reporting that the material -- which is actually a bright red plant sap used for thousands of years in traditional Chinese medicine -- contains chemicals that were effective in laboratory experiments in fighting bacteria that cause millions of cases of gastrointestinal disease each year.

Is There Any Alternative To Control Multisteps Of Ulcers?

Wed, 24 Oct 2007 10:27:27 EDT

Ulcers are a worldwide challenging disease, and researchers have long been seeking effective antiulcer alternatives. A research group in India has revealed that a bioactive polysaccharide from an edible root, Decalepis hamiltonii, commonly called swallow root, could offer protection at all critical steps of gastric ulcer.

HIV-positive Patients have a Low Prevalence Of H Pylori In Gut

Tue, 16 Oct 2007 13:15:15 EDT

A research group in China has found that the prevalence of H pylori infection and peptic ulcer in HIV-positive patients was lower than that of the general population. Helicobacter pylori has been extensively studied and shown to be the main cause of chronic gastritis and peptic ulcer in the HIV-negative population. Patients with chronic active gastritis have evidence of H pylori infection in over 90% of cases and in 70-100% of those with peptic ulcer disease.

Specific H. Pylori Strains Are Associated With Precancerous Lesions

Tue, 28 Aug 2007 18:04:04 EDT

A new study suggests that previous estimates of the risk of gastric cancer following infection with the bacterium Helicobacter pylori may be too low. The research identifies certain strains of the bacterium associated with precancerous gastric lesions. H. pylori live in the human stomach. But many people with H. pylori infections never develop gastric cancer. Some evidence suggests that genetic variation among different strains of the bacteria may explain why some infections result in gastric cancer while others do not.

Combined Immunization Methods May Offer Long-Term Protection Against H. Pylori Infection

Mon, 16 Jul 2007 19:17:17 EDT

New immunization methods offer long-term protection against H. pylori in humans and may contribute to a possible ulcer vaccine in the future say researchers from the University of California, Davis.

Salt Increases Ulcer-bug Virulence

Tue, 22 May 2007 09:11:11 EDT

Scientists have identified yet another risk from a high-salt diet. High concentrations of salt in the stomach appear to induce gene activity in the ulcer-causing bacterium Helicobacter pylori, making it more virulent and increasing the likelihood of an infected person developing a severe gastric disease.

New Potential Health Benefit Of Olive Oil For Peptic Ulcer Disease

Mon, 12 Feb 2007 10:17:17 EST

Already fabled for an array of health benefits, extra virgin olive oil -- a centerpiece of the Mediterranean Diet -- may have a new role in helping to prevent and treat Helicobacter pylori (H. pylori) infections, which cause millions of cases of gastritis and peptic ulcer disease each year, researchers in Spain report.

Prehistoric Origins Of Stomach Ulcers Uncovered

Wed, 07 Feb 2007 17:19:19 EST

Scientists have discovered that the ubiquitous bacteria that causes most painful stomach ulcers has been present in the human digestive system since modern man migrated from Africa over 60,000 years ago. They compared DNA sequence patterns of humans and the Helicobacter pylori bacteria now known to cause most stomach ulcers and found that the genetic differences between human populations that arose as they dispersed from Eastern Africa over thousands of years are mirrored in H. pylori.

Bacteria Increase Risk Of Lower Stomach Cancer, Decreases Risk Of Upper

Wed, 18 Oct 2006 09:49:49 EDT

The bacteria Helicobacter pylori substantially increase the risk of cancer in the lower stomach, but it may decrease the risk of cancer near the junction between the esophagus and the stomach, according to a study in the October 19 Journal of the National Cancer Institute. This finding may help explain the changing rates and distributions of these cancers in Western countries over the past century.

Stomach Receptor For H. Pylori Discovered

Sat, 06 May 2006 10:38:38 EDT

Scientists have determined that decay-accelerating factor (DAF), a protein found in epithelial cells in the stomach, acts as a receptor for the bacteria Helicobacter pylori. Blocking this interaction could lead to new drugs that reduce the risk of peptic ulcer disease or gastric cancer. The research appears as the "Paper of the Week" in the May 12 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Low-dose Aspirin And Stomach Ulcer Medications Better For Heart Patients With Gastrointestinal Complications

Mon, 24 Jan 2005 00:49:49 EST

Heart patients with gastrointestinal complications should use low doses of aspirin combined with drugs that treat stomach ulcers rather than taking the anti-platelet drug Plavix, which has been thought to reduce bleeding ulcers, according to a gastroenterologist at UT Southwestern Medical Center and the Dallas Veterans Affairs Medical Center.

Patients Undergoing Weight Loss Surgery Have High Rates Of Bacterial Infection Associated With Gastrointestinal Disease

Tue, 19 Oct 2004 08:39:39 EDT

The prevalence of Helicobacter pylori (a type of bacteria associated with gastrointestinal disorders) is high among patients about to undergo weight loss surgery, and treatment to eradicate the bacterial infection before surgery may be beneficial, according to an article in the October issue of Archives of Surgery, one of the JAMA/Archives journals.

For Those Who Take Painkillers Regularly, A Heartburn Pill A Day May Keep Ulcers Away

Wed, 15 Oct 2003 02:58:58 EDT

For those who take certain painkiller drugs regularly to help ease arthritis pain or other chronic aches, the relief comes with a tradeoff: a quadrupled chance of developing painful ulcers over the long term, as their digestive systems brim with acid that erodes the lining of their stomachs and upper intestinal tract.

Vitamin C May Protect Against Ulcer-Causing Bacteria

Tue, 05 Aug 2003 07:25:25 EDT

A study led by researchers at the San Francisco VA Medical Center (SFVAMC) has found that the lower the level of vitamin C in the blood the more likely a person will become infected by Helicobacter pylori, the bacteria that can cause peptic ulcers and stomach cancer.